4-Hydroxybenzoic Acid → Benzoic acid, 4-(acetyloxy)-

HRID 1871203Notes

Reaction equation

HRID 1871203 reaction equation
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1.[C:11](O)(=[O:13])[CH3:12]>S(=O)(=O)(O)O.O>[C:11]([O:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1)(=[O:13])[CH3:12]

Participants

5

Reactant 2

HCID 1354-Hydroxybenzoic AcidHCID 176Acetic Acid

Product 1

HCID 16865Benzoic acid, 4-(acetyloxy)-

Reagents, catalysts & solvents 2

HCID 1118Sulfuric AcidCatalystHCID 962WaterSolvent2×

Conditions

Temperature
80 °C

Procedure

6 Grams of 4-hydroxybenzoic acid and 8.2 g of anhydrous acetic acid were placed in a two-necked flask and mixed. While the mixture was cooled with water, 5 drops of sulfuric acid was added. After termination of heat generation, the mixture was heated at 80° C. for 30 minutes. Then, the reaction mixture was poured into cold water, and a precipitated crystal was filtered.

Workup

  1. additionmixed
  2. additionwas added
  3. filtrationa precipitated crystal was filtered

Sources & evidence

ORD record
ord-20fbf0f381764177b0bf1f8430bf20aa
Source dataset
uspto-grants-2000_08
Patent number
US06103517

Reaction notes

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