Hydrazine hydrate (1:1) → (cis)-4-(3-Cyclopentyloxy-4-methoxyphenyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-one

HRID 1871364Notes

Reaction equation

HRID 1871364 reaction equation
O.NN.[CH3:4][O:5][C:6]1[CH:7]=[C:8]([C:14]2[C@H:23]3[C@H:18]([CH2:19][CH2:20][CH2:21][CH2:22]3)[C:17](=[O:24])[NH:16][N:15]=2)[CH:9]=[CH:10][C:11]=1[O:12][CH3:13]>>[CH:4]1([O:5][C:6]2[CH:7]=[C:8]([C:14]3[C@H:23]4[C@H:18]([CH2:19][CH2:20][CH2:21][CH2:22]4)[C:17](=[O:24])[NH:16][N:15]=3)[CH:9]=[CH:10][C:11]=2[O:12][CH3:13])[CH2:10][CH2:11][CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 10913208(cis)-4-(3,4-Dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-one

Product 1

HCID 11727597(cis)-4-(3-Cyclopentyloxy-4-methoxyphenyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-one

Procedure

Prepared from compound D (see starting compounds) and hydrazine hydrate as described for compound 1. M.p. 175-176° C.

Sources & evidence

ORD record
ord-b95ba89c85bc473ea636a121495c285b
Source dataset
uspto-grants-2000_08
Patent number
US06103718

Reaction notes

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