Ethyl Bromide → (cis)-4-(3,4-Dimethoxyphenyl)-2-ethyl-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-one

HRID 1871367Notes

Reaction equation

HRID 1871367 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C@H:20]3[C@H:15]([CH2:16][CH2:17][CH2:18][CH2:19]3)[C:14](=[O:21])[NH:13][N:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].Br[CH2:23][CH3:24].COC1C=C(C2[C@H]3[C@H](CCCC3)C(=O)N(C)N=2)C=CC=1OC>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C@H:20]3[C@H:15]([CH2:16][CH2:17][CH2:18][CH2:19]3)[C:14](=[O:21])[N:13]([CH2:23][CH3:24])[N:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

4

Reactant 3

HCID 6332Ethyl BromideHCID 10913208(cis)-4-(3,4-Dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-oneHCID 70003942(cis)-4-(3,4-Dimethoxyphenyl)-2-methyl-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-one

Product 1

HCID 70301348(cis)-4-(3,4-Dimethoxyphenyl)-2-ethyl-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-one

Procedure

Prepared from compound 1 and bromoethane as described for compound 8. Crystallized from methanol. M.p. 105-106° C.

Workup

  1. customCrystallized from methanol

Sources & evidence

ORD record
ord-5a5ebdcf575f4ff58b62dd547161fa2a
Source dataset
uspto-grants-2000_08
Patent number
US06103718

Reaction notes

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