Water → (cis)-4-(3-Ethoxy-4-methoxyphenyl)-2-cyclopentyl-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one

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Reaction Steps

A solution of 0.5 g of compound 6, 0.8 g of K2CO3 and 0.3 g of ethyliodide was stirred in 20 ml of N-methyl-pyrrolidinone for 4 h at 70° C. After cooling to room temperature, the reaction mixture was poured into 200 ml of water and this mixture was extracted with diethyl ether. After drying over magnesium sulfate, the solvent was evaporated and the compound crystallized from methanol, M.p. 124-127° C.

Provenance & Evidence