Cyclohexane, (bromomethyl)- → HCID 70003966, compound

HRID 1871377Notes

Reaction equation

HRID 1871377 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C@H:20]3[C@H:15]([CH2:16][CH2:17][CH2:18][CH2:19]3)[C:14](=[O:21])[NH:13][N:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].Br[CH2:23][CH:24]1[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1.COC1C=C(C2[C@H]3[C@H](CCCC3)C(=O)N(C)N=2)C=CC=1OC>>[CH:24]1([CH2:23][N:13]2[N:12]=[C:11]([C:5]3[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=3)[C@H:20]3[C@H:15]([CH2:16][CH2:17][CH2:18][CH2:19]3)[C:14]2=[O:21])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1

Participants

4

Reactant 3

HCID 137636Cyclohexane, (bromomethyl)-HCID 10913208(cis)-4-(3,4-Dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-oneHCID 70003942(cis)-4-(3,4-Dimethoxyphenyl)-2-methyl-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-one

Product 1

HCID 70003966HCID 70003966, compound

Procedure

Prepared from compound 1 and bromomethylcyclohexane as described for compound 8. Purified by chromatography (dichloromethane). Crystallized from petroleum ether (60-95° C.). M.p. 137-139° C.

Workup

  1. customPurified by chromatography (dichloromethane)
  2. customCrystallized from petroleum ether (60-95° C.)

Sources & evidence

ORD record
ord-dd5e2bfd88d643d4894a36d4ed8c6976
Source dataset
uspto-grants-2000_08
Patent number
US06103718

Reaction notes

Loading…