Benzene, (3-bromopropoxy)- → HCID 86755610, compound

HRID 1871388Notes

Reaction equation

HRID 1871388 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C@H:20]3[C@H:15]([CH2:16][CH2:17][CH2:18][CH2:19]3)[C:14](=[O:21])[NH:13][N:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[O:22]([CH2:29][CH2:30][CH2:31]Br)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.COC1C=C(C2[C@H]3[C@H](CCCC3)C(=O)N(C)N=2)C=CC=1OC>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C@H:20]3[C@H:15]([CH2:16][CH2:17][CH2:18][CH2:19]3)[C:14](=[O:21])[N:13]([CH2:31][CH2:30][CH2:29][O:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[N:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

4

Reactant 3

HCID 68522Benzene, (3-bromopropoxy)-HCID 10913208(cis)-4-(3,4-Dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-oneHCID 70003942(cis)-4-(3,4-Dimethoxyphenyl)-2-methyl-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-one

Product 1

HCID 86755610HCID 86755610, compound

Procedure

Prepared from compound 1 and 3-phenoxy-1-bromopropane as described for compound 8. Purified by chromatography (dichloromethane). Crystallized from petroleum ether (60°-80° C.). M.p. 78°-81° C.

Workup

  1. customPurified by chromatography (dichloromethane)
  2. customCrystallized from petroleum ether (60°-80° C.)

Sources & evidence

ORD record
ord-6ce147bcd8cc48c5826bf0a3872268b9
Source dataset
uspto-grants-2000_08
Patent number
US06103718

Reaction notes

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