Phenylhydrazine → (cis)-4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-phenyl-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one

HRID 1871392Notes

Reaction equation

HRID 1871392 reaction equation
[C:1]1([NH:7][NH2:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:9][O:10][C:11]1[CH:12]=[C:13]([C:19]2[C@H:28]3[C@H:23]([CH2:24][CH2:25][CH2:26][CH2:27]3)[C:22](=[O:29])N(CCO)N=2)[CH:14]=[CH:15][C:16]=1[O:17][CH3:18]>>[CH:9]1([O:10][C:11]2[CH:12]=[C:13]([C:19]3[C@H:28]4[C@H:23]([CH2:24][CH:25]=[CH:26][CH2:27]4)[C:22](=[O:29])[N:7]([C:1]4[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=4)[N:8]=3)[CH:14]=[CH:15][C:16]=2[O:17][CH3:18])[CH2:3][CH2:2][CH2:1][CH2:6]1

Participants

3

Procedure

Prepared from compound E (see starting compounds) and phenylhydrazine as described for compound 35. Crystallization from methanol. M.p. 134°-135° C.

Workup

  1. customCrystallization from methanol

Sources & evidence

ORD record
ord-20e9a415904e452e9b2e5302a7c04afe
Source dataset
uspto-grants-2000_08
Patent number
US06103718

Reaction notes

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