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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1871407Generated: November 2, 2026

4-(Chloromethyl)benzoic acid → (cis)-4-(4-(3,4-Diethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydro-1H-phthalazin-2-yl-methyl)benzoic acid

https://huagongshe.com/reaction/1871407

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Chloromethyl)benzoic acidHCID 74234—
Reactant(cis)-4-(3,4-Diethoxyphenyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-onHCID 70002320—
Reactant(cis)-4-(4-(3,4-Dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydro-1H-phthalazin-2-ylmethyl)-benzoic acidHCID 86755615—
Product(cis)-4-(4-(3,4-Diethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydro-1H-phthalazin-2-yl-methyl)benzoic acidHCID 86755616—

Reaction Steps

Prepared from compound 7 and 4-chloromethylbenzoic acid as described for compound 83. Purified by chromatography (dichloromethane). Crystallized from diethyl ether. M.p. 152°-154° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06103718
Source datasetuspto-grants-2000_08
ORD IDord-22b4b89fece345fa8460d5213a2d2755
Source noteuspto-grants-2000_08