Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1871410Generated: November 3, 2026

3-(Bromomethyl)benzoic acid → (cis)-3-(4-(3,4-Dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydro-1H-phthalazin-2-ylmethyl)benzoic acid

https://huagongshe.com/reaction/1871410

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Bromomethyl)benzoic acidHCID 245650—
Reactant(cis)-4-(3,4-Dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-oneHCID 10913208—
Reactant(cis)-4-(4-(3,4-Dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydro-1H-phthalazin-2-ylmethyl)-benzoic acidHCID 86755615—
Product(cis)-3-(4-(3,4-Dimethoxyphenyl)-1-oxo-4a,5,6,7,8,8a-hexahydro-1H-phthalazin-2-ylmethyl)benzoic acidHCID 9866910—

Reaction Steps

Prepared from compound 1 and 3-bromomethylbenzoic acid as described for compound 83. Purified by chromatography (ethyl acetate). Crystallized from diethyl ether. M.p. 133°-136° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06103718
Source datasetuspto-grants-2000_08
ORD IDord-d078ea558e744fc3ade6f57c1302c972
Source noteuspto-grants-2000_08