3,5-Dimethoxybenzyl chloride → HCID 70002409, compound

HRID 1871415Notes

Reaction equation

HRID 1871415 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C@H:20]3[C@H:15]([CH2:16][CH2:17][CH2:18][CH2:19]3)[C:14](=[O:21])[NH:13][N:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[CH3:22][O:23][C:24]1[CH:25]=[C:26]([CH:29]=[C:30]([O:32][CH3:33])[CH:31]=1)[CH2:27]Cl.C(N1N=C(C2C=CC(OC)=C(OC)C=2)[C@H]2[C@H](CCCC2)C1=O)C1C=CC=CC=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C@H:20]3[C@H:15]([CH2:16][CH2:17][CH2:18][CH2:19]3)[C:14](=[O:21])[N:13]([CH2:27][C:26]3[CH:29]=[C:30]([O:32][CH3:33])[CH:31]=[C:24]([O:23][CH3:22])[CH:25]=3)[N:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

4

Reactant 3

HCID 27583953,5-Dimethoxybenzyl chlorideHCID 10913208(cis)-4-(3,4-Dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-oneHCID 70001660(cis)-2-Benzyl-4-(3,4-dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-one

Product 1

HCID 70002409HCID 70002409, compound

Procedure

Prepared from compound 1 and 3,5-dimethoxybenzylchloride as described for compound 78. Purified by chromatography (dichloromethane). Crystallized from methanol. M.p. 114°-117° C.

Workup

  1. customPurified by chromatography (dichloromethane)
  2. customCrystallized from methanol

Sources & evidence

ORD record
ord-00b7f9f09fbe47bfb225621b225870d5
Source dataset
uspto-grants-2000_08
Patent number
US06103718

Reaction notes

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