Phenethyl bromide → HCID 70003823, compound

HRID 1871431Notes

Reaction equation

HRID 1871431 reaction equation
Br[CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH3:10][O:11][C:12]1[CH:13]=[C:14]([C:20]2[C@H:29]3[C@H:24]([CH2:25][CH2:26][CH2:27][CH2:28]3)[C:23](=[O:30])[NH:22][N:21]=2)[CH:15]=[CH:16][C:17]=1[O:18][CH3:19].C(N1N=C(C2C=CC(OC)=C(OC)C=2)[C@H]2[C@H](CCCC2)C1=O)C1C=CC=CC=1>>[CH3:10][O:11][C:12]1[CH:13]=[C:14]([C:20]2[C@H:29]3[C@H:24]([CH2:25][CH2:26][CH2:27][CH2:28]3)[C:23](=[O:30])[N:22]([CH2:2][CH2:3][C:4]3[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=3)[N:21]=2)[CH:15]=[CH:16][C:17]=1[O:18][CH3:19]

Participants

4

Reactant 3

HCID 7666Phenethyl bromideHCID 10913208(cis)-4-(3,4-Dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-oneHCID 70001660(cis)-2-Benzyl-4-(3,4-dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-one

Product 1

HCID 70003823HCID 70003823, compound

Procedure

Prepared from 2-bromoethylbenzene and compound 1 as described for compound 78. Purified by chromatography [ethyl acetate: petroleum ether (60°-80° C.)/1:3]. Crystallized from methanol. M.p. 99°-100° C.

Workup

  1. customPurified by chromatography [ethyl acetate: petroleum ether (60°-80° C.)/1:3]
  2. customCrystallized from methanol

Sources & evidence

ORD record
ord-c63a4fc6f21f4dd9b76e43acb6f222f4
Source dataset
uspto-grants-2000_08
Patent number
US06103718

Reaction notes

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