HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 70002230, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | (cis)-4-(3,4-Dimethoxyphenyl)-2-(2-hydroxy-1-ethyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-one | HCID 86755609 | — |
| Product | HCID 70002230 | HCID 70002230 | — |
Reaction Steps
A solution of 25 mmol of bromine in 10 ml of dichloromethane was added to a solution of 25 mmol of triphenylphosphine in 50 ml of dichloromethane at 0° C. under a flow of nitrogen, followed by the addition of 25 mmol of compound 35 in 25 ml of dichloromethane. After complete addition, the mixture was stirred for 2 h at room temperature. The reaction mixture was washed with aqueous sodium carbonate, dried over magnesium sulfate and evaporated. The compound was crystallized from methanol. M.p. 134°-136° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06103718 |
| Source dataset | uspto-grants-2000_08 |
| ORD ID | ord-a9214c09a16845bf90f404c90b8c64d8 |
| Source note | uspto-grants-2000_08 |