(Tetrahydro-2H-pyran-4-yl)hydrazine → (cis)-4-(3,4-Dimethoxyphenyl)-2-(tetrahydropyran-4-yl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one
Reaction equation
[NH:1]([CH:3]1[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1)[NH2:2].[CH3:9][O:10][C:11]1[CH:12]=[C:13]([C:19]2[C@H:28]3[C@H:23]([CH2:24][CH2:25][CH2:26][CH2:27]3)[C:22](=[O:29])N(CCO)N=2)[CH:14]=[CH:15][C:16]=1[O:17][CH3:18]>>[CH3:9][O:10][C:11]1[CH:12]=[C:13]([C:19]2[C@H:28]3[C@H:23]([CH2:24][CH:25]=[CH:26][CH2:27]3)[C:22](=[O:29])[N:1]([CH:3]3[CH2:8][CH2:7][O:6][CH2:5][CH2:4]3)[N:2]=2)[CH:14]=[CH:15][C:16]=1[O:17][CH3:18]Participants
3
Procedure
Prepared from compound C and 4-hydrazinotetrahydropyran as described for compound 35. Crystallized from methanol. M.p. 175°-177° C.
Workup
- customCrystallized from methanol
Sources & evidence
- ORD record
- ord-3215fb063ad84d429105f334f9a0091c
- Source dataset
- uspto-grants-2000_08
- Patent number
- US06103718
Reaction notes
Loading…