1-(Benzyloxy)-2-(chloromethyl)benzene → (cis)-4-(3,4-Dimethoxyphenyl)-2-(2-benzyloxybenzyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-one

HRID 1871444Notes

Reaction equation

HRID 1871444 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C@H:20]3[C@H:15]([CH2:16][CH2:17][CH2:18][CH2:19]3)[C:14](=[O:21])[NH:13][N:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[CH2:22]([O:29][C:30]1[CH:37]=[CH:36][CH:35]=[CH:34][C:31]=1[CH2:32]Cl)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C@H:20]3[C@H:15]([CH2:16][CH2:17][CH2:18][CH2:19]3)[C:14](=[O:21])[N:13]([CH2:32][C:31]3[CH:34]=[CH:35][CH:36]=[CH:37][C:30]=3[O:29][CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[N:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

3

Reactant 2

HCID 5635071-(Benzyloxy)-2-(chloromethyl)benzeneHCID 10913208(cis)-4-(3,4-Dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-one

Product 1

HCID 70003457(cis)-4-(3,4-Dimethoxyphenyl)-2-(2-benzyloxybenzyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-one

Procedure

Prepared from compound 1 and 2-benzyloxybenzylchloride as described for component 78. Purified by chromatography [ethyl acetate/petroleum ether (60°-80° C.), 1:3]. M.p. colourless oil.

Workup

  1. customPurified by chromatography [ethyl acetate/petroleum ether (60°-80° C.), 1:3]

Sources & evidence

ORD record
ord-fbd8e85655094d3c8d5da0814da40927
Source dataset
uspto-grants-2000_08
Patent number
US06103718

Reaction notes

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