HRID1871470

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6340

Ethane, iodo-

C2H5I

HCID7841

Allyl bromide

C3H5Br

HCID15462240

未命名化合物

HCID18691183

未命名化合物

2 次

PRODUCTS

生成物

结构：CCN(CC)c1c(-c2ccccc2C)nc2c3cccc(Cl)c3ccn12

HCID15462575

未命名化合物

结构：CCNc1c(-c2ccccc2C)nc2c3cccc(Cl)c3ccn12

HCID18691152

未命名化合物

PROCEDURE

实验过程

Example 10 was repeated except that 3-amino-7-chloro-2-(2-methylphenyl)imidazo[2,1-a]isoquinoline (Compound 5) and ethyl iodide were used in place of 3-amino-2-(2-methylphenyl)imidazo[2,1-a]isoquinoline and allyl bromide, which gave 7-chloro-3-ethylamino-2-(2-methylphenyl)imidazo[2,1-a]isoquinoline (Compound 159) as yellow needles and 7-chloro-3-diethylamino-2-(2-methylphenyl)imidazo[2,1-a]isoquinoline (Compound 199) as colorless needles.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-281c659aa4674b00ae7101811f53c7df
来源数据集: uspto-grants-2000_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06103736
来源说明: uspto-grants-2000_08

反应 SMILES

[NH2:1][C:2]1[N:6]2[CH:7]=[CH:8][C:9]3[C:14]([C:5]2=[N:4][C:3]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[CH3:22])=[CH:13][CH:12]=[CH:11][C:10]=3[Cl:15].[CH2:23](I)[CH3:24].N[C:27]1N2C=CC3C(C2=N[C:28]=1C1C=CC=CC=1C)=CC=CC=3.[CH2:47](Br)[CH:48]=C>>[Cl:15][C:10]1[CH:11]=[CH:12][CH:13]=[C:14]2[C:9]=1[CH:8]=[CH:7][N:6]1[C:2]([NH:1][CH2:23][CH3:24])=[C:3]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[CH3:22])[N:4]=[C:5]12.[Cl:15][C:10]1[CH:11]=[CH:12][CH:13]=[C:14]2[C:9]=1[CH:8]=[CH:7][N:6]1[C:2]([N:1]([CH2:47][CH3:48])[CH2:27][CH3:28])=[C:3]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[CH3:22])[N:4]=[C:5]12