Glycine methyl ester hydrochloride → HCID 88158691, compound

HRID 1871475Notes

Reaction equation

HRID 1871475 reaction equation
Cl.[CH3:2][O:3][C:4](=[O:7])[CH2:5][NH2:6].[C:8](=[NH:21])([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>C(Cl)Cl>[CH3:2][O:3][C:4](=[O:7])[CH2:5][NH2:6].[C:8](=[NH:21])([C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 122755Glycine methyl ester hydrochlorideHCID 136809Benzophenone imine

Product 1

HCID 88158691HCID 88158691, compoundYield 98.94%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a flame dried 250 ml round bottom flask, flushed with Argon, was added glycine methyl ester hydrochloride (10.0 g, 79.64 mmol), benzophenone-imine (13.36 ml, 79.64 mmol) and CH2Cl2 (100 ml). The mixture was stirred at room temperature for 18 hrs, filtered and evaporated to dryness in vacuo. The concentrated yellow oil so obtained was then recrystallized, giving 19.96 g (98.94% yield) of the title product as a white solid.

Workup

  1. customTo a flame dried 250 ml round bottom flask
  2. customflushed with Argon
  3. filtrationfiltered
  4. customevaporated to dryness in vacuo
  5. customThe concentrated yellow oil so obtained
  6. customwas then recrystallized

Sources & evidence

ORD record
ord-3a27a7d9dadf41cbbb8a368dc0756780
Source dataset
uspto-grants-2000_08
Patent number
US06103743

Reaction notes

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