Methanesulfonyl chloride → 4-Methanesulfonamidophthalimide

HRID 1871486Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1871486
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[NH2:6][C:7]1[CH:8]=[C:9]2[C:14](=[O:15])[NH:13][C:11](=[O:12])[C:10]2=[CH:16][CH:17]=1>N1C=CC=CC=1>[CH3:1][S:2]([NH:6][C:7]1[CH:8]=[C:9]2[C:14](=[O:15])[NH:13][C:11](=[O:12])[C:10]2=[CH:16][CH:17]=1)(=[O:4])=[O:3]

Komponenten

4

Edukt 2

HCID 31297Methanesulfonyl chlorideHCID 729154-Aminophthalimide

Produkt 1

HCID 9750204-MethanesulfonamidophthalimideAusbeute 76,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

Methanesulfonylchloride (2.6 ml, 0.034 mol) was added dropwise to a stirred suspension of 4-aminophthalimide (5.0 g, 0.031 mol) in pyridine (50 ml). The mixture was stirred for 48 h under N2 at room temperature, after which time the solid formed was isolated by filtration, washing well with H2O and CH2Cl2 and then dried in vacuo to afford the subtitle compound as a colourless solid (5.67 g, 76%). Rf 0.52 (CH2Cl2/MeOH/0.88NH3 90/10/1, v/v). MS m/z 241 (MH+).

Aufarbeitung

  1. customafter which time the solid formed
  2. customwas isolated by filtration
  3. washwashing well with H2O and CH2Cl2
  4. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-6ab5593218dc40639a7286e41e380aa0
Quelldatensatz
uspto-grants-2000_08
Patentnummer
US06103738

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