p-(Trifluoromethoxy)benzenesulphonyl chloride → N-[4-[2-(Propylamino)ethyl)phenyl]-4-(trifluoromethoxy)-benzenesulfonamidehydrochloride

HRID 1871520Notes

Reaction equation

HRID 1871520 reaction equation
[F:1][C:2]([F:15])([F:14])[O:3][C:4]1[CH:9]=[CH:8][C:7]([S:10](Cl)(=[O:12])=[O:11])=[CH:6][CH:5]=1.[NH2:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][CH2:24][NH:25][CH:26](C(OC(C)(C)C)=O)[CH2:27][CH3:28])=[CH:19][CH:18]=1>>[F:1][C:2]([F:15])([F:14])[O:3][C:4]1[CH:9]=[CH:8][C:7]([S:10]([NH:16][C:17]2[CH:18]=[CH:19][C:20]([CH2:23][CH2:24][NH:25][CH2:26][CH2:27][CH3:28])=[CH:21][CH:22]=2)(=[O:12])=[O:11])=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 523102p-(Trifluoromethoxy)benzenesulphonyl chlorideHCID 18691624HCID 18691624, compound

Product 1

HCID 9887351N-[4-[2-(Propylamino)ethyl)phenyl]-4-(trifluoromethoxy)-benzenesulfonamidehydrochloride

Procedure

Using procedure 4, 4-trifluoromethoxybenzenesulfonyl chloride was added to 2-(4-aminophenyl)ethyl-1-(tert-butoxycarbonyl)propylamine to give the title compound as a solid, m.p. 151-154° C.

Sources & evidence

ORD record
ord-1ad4270ffba54925a38b6abc3b47ed6f
Source dataset
uspto-grants-2000_08
Patent number
US06103766

Reaction notes

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