Water → HCID 54465243, compound

HRID 1871636Notes

Reaction equation

O.[OH-].[Li+].O.[C:5]1([C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)[CH:10]=[CH:9][C:8]([C:11](=[N:13][O:14][CH2:15][CH2:16][O:17][C:18]2[CH:23]=[CH:22][C:21]([CH2:24][CH:25]([NH:31][C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[C:26]([O:28]CC)=[O:27])=[CH:20][CH:19]=2)[CH3:12])=[CH:7][CH:6]=1>O1CCOCC1>[C:5]1([C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)[CH:6]=[CH:7][C:8]([C:11](=[N:13][O:14][CH2:15][CH2:16][O:17][C:18]2[CH:23]=[CH:22][C:21]([CH2:24][CH:25]([NH:31][C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=3)[C:26]([OH:28])=[O:27])=[CH:20][CH:19]=2)[CH3:12])=[CH:9][CH:10]=1

Participants

Conditions

Temperature: 60 °C

Procedure

A solution of 72 mg of lithium hydroxide monohydrate and 3 ml of water was added to a solution of 282 mg of ethyl 3-[4-[2-[[1-(4-biphenylyl)ethylidene]aminoxy]ethoxy]phenyl]-2-(phenylamino)propionate obtained in Example 9 in 3 ml of dioxane. The mixture was stirred at 60° C. for one hour. After the reaction, the reaction mixture was concentrated and diluted with water. Then, 1.71 ml of 1N hydrochloric acid was added to the resulting mixture, and the product thus obtained was extracted with a large amount of hot ethyl acetate. The extract was concentrated to about 5 ml, and 229 mg of the desired compound was obtained by filtration.

Workup

customAfter the reaction
concentrationthe reaction mixture was concentrated
additiondiluted with water
additionThen, 1.71 ml of 1N hydrochloric acid was added to the resulting mixture
customthe product thus obtained
extractionwas extracted with a large amount of hot ethyl acetate
concentrationThe extract was concentrated to about 5 ml

Sources & evidence

ORD record: ord-9cf649af3d8243c9bb7dab3cf0a48056
Source dataset: uspto-grants-2000_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06103907

Reaction notes

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