Lithium hydroxide, monohydrate → HCID 53690010, compound

HRID 1871638Notes

Reaction equation

HRID 1871638 reaction equation
[C:1]1([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH:6]=[CH:5][C:4]([C:7](=[N:9][O:10][CH2:11][CH2:12][O:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][CH:21]([C:27]3[NH:28][CH:29]=[CH:30][CH:31]=3)[C:22]([O:24]CC)=[O:23])=[CH:16][CH:15]=2)[CH3:8])=[CH:3][CH:2]=1.O.[OH-].[Li+]>>[C:1]1([C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=2)[CH:6]=[CH:5][C:4]([C:7](=[N:9][O:10][CH2:11][CH2:12][O:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][CH:21]([C:27]3[NH:28][CH:29]=[CH:30][CH:31]=3)[C:22]([OH:24])=[O:23])=[CH:16][CH:15]=2)[CH3:8])=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 86755636HCID 86755636, compound

Product 1

HCID 53690010HCID 53690010, compoundYield 85.7%

Procedure

Reaction and post-treatment were carried out according to Example 10 using 167 mg of ethyl 3-[4-[2-[[1-(4-biphenylyl)ethylidene]aminoxy]ethoxy]phenyl]-2-pyrrolylpropionate obtained in Example 13 and 42 mg of lithium hydroxide monohydrate to obtain 135 mg of the desired compound as crystals.

Workup

  1. customReaction

Sources & evidence

ORD record
ord-0c3c2a34d9d447f998c36003ab2b6714
Source dataset
uspto-grants-2000_08
Patent number
US06103907

Reaction notes

Loading…