Hydrochloric Acid → HCID 53945355, compound

HRID 1871639Notes

Reaction equation

HRID 1871639 reaction equation
Cl.[CH2:2]([NH:4][CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][O:21][N:22]=[C:23]([C:25]2[CH:30]=[CH:29][C:28]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][N:32]=3)=[CH:27][CH:26]=2)[CH3:24])=[CH:14][CH:13]=1)[C:6]([O:8]CC)=[O:7])[CH3:3].[OH-].[Na+].Cl>>[CH2:2]([NH:4][CH:5]([CH2:11][C:12]1[CH:13]=[CH:14][C:15]([O:18][CH2:19][CH2:20][O:21][N:22]=[C:23]([C:25]2[CH:26]=[CH:27][C:28]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][N:32]=3)=[CH:29][CH:30]=2)[CH3:24])=[CH:16][CH:17]=1)[C:6]([OH:8])=[O:7])[CH3:3]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86755637HCID 86755637, compound

Product 1

HCID 53945355HCID 53945355, compound

Procedure

Reaction was carried out according to Example 2 using 273 mg of ethyl 2-ethylamino-3-[4-[2-[[1-[4-(2-pyridyl)phenyl]ethylidene]aminoxy]ethoxy]phenyl]propionate obtained in Example 15 and 2.4 ml of a 1N aqueous sodium hydroxide solution. When the pH of the reaction mixture thus obtained was adjusted to a value of 4 with 1N hydrochloric acid, the desired compound was obtained as a precipitate. The precipitate was collected by filtration and washed with water to obtain 186 mg of the desired compound.

Workup

  1. customReaction
  2. customWhen the pH of the reaction mixture thus obtained

Sources & evidence

ORD record
ord-5b8c6ca5e188448a9e2299453aac0bc8
Source dataset
uspto-grants-2000_08
Patent number
US06103907

Reaction notes

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