Sodium hydride → HCID 18625915, compound

HRID 1871656Notes

Reaction equation

HRID 1871656 reaction equation
[CH2:1]([CH:5]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH2:2][CH2:3][CH3:4].[CH2:16]([O:23][C:24]1[CH:31]=[CH:30][C:27]([CH2:28]Cl)=[CH:26][CH:25]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[H-].[Na+]>>[CH2:16]([O:23][C:24]1[CH:31]=[CH:30][C:27]([CH2:28][C:5]([CH2:1][CH2:2][CH2:3][CH3:4])([C:6]([O:8][CH2:9][CH3:10])=[O:7])[C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:26][CH:25]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 67244Diethyl butylmalonateHCID 700424-Benzyloxybenzyl chloride

Product 1

HCID 18625915HCID 18625915, compoundYield 89.1%

Procedure

Reaction and post-treatment were carried out according to Reference example 12(a) using 2.16 g of diethyl butylmalonate, 2.44 g of 4-benzyloxybenzyl chloride and 480 mg of sodium hydride (55% oil suspension) to obtain 3.67 g of the desired compound as crystals.

Workup

  1. customReaction

Sources & evidence

ORD record
ord-e8b2ec36718d423f9f79ae687a12f88d
Source dataset
uspto-grants-2000_08
Patent number
US06103907

Reaction notes

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