Ethanol → tert-Butyl 4-(methylamino)piperidine-1-carboxylate

HRID 187175Notes

Reaction equation

HRID 187175 reaction equation
[BH4-:17].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11](=[O:14])[CH2:12][CH2:13]1.[CH3:15][NH2:16].[CH3:20][CH2:21][OH:22].[CH3:23][CH:24]([CH3:25])[O-:26].[CH3:28][CH:29]([CH3:30])[O-:31].[CH3:32][CH:33]([CH3:34])[O-:35].[CH3:36][CH:37]([CH3:38])[O-:39].[Na+:18].[OH2:19].[Ti+4:27]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([NH:16][CH3:15])[CH2:12][CH2:13]1

Participants

9

Reactant 8

HCID 702EthanolHCID 923Sodium ionHCID 962WaterHCID 6329MethylamineHCID 28123BorohydrideHCID 114942Titanium cation (4+)HCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 3260420Isopropanolate4×

Product 1

HCID 15380702tert-Butyl 4-(methylamino)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-f480e9dcd1ee42f59b0953355e09faad
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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