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HRID18718

反应详情

EQUATION

反应方程式

HRID 18718 的结构方程式

REACTANTS

反应物

2
结构：CI
HCID6328

Methyl iodide

CH3I

结构：Cc1ccc([C@H]2NC(=S)N[C@H]2c2ccc(C)cc2)cc1
HCID86596316

未命名化合物

PRODUCTS

生成物

1
结构：CSC1=N[C@@H](c2ccc(C)cc2)[C@@H](c2ccc(C)cc2)N1.I
HCID68570732

未命名化合物

收率 96.8%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A mixture of cis-4,5-bis-(4-methylphenyl)imidazolidine-2-thione (31) (5.2 g, 0.0184 mol) and methyl iodide (1.72 mL, 0.0276 mol) in abs. EtOH (30 mL) is heated at 90° C. overnight. The reaction mixture is cooled to rt, concentrated in vacuo, and the residue suspended in abs EtOH:Et2O. The insoluble material is filtered to give 7.56 g of the product 48. 1H NMR (DMSO-d6) δ 10.68 (s, 2 H), 7.00-6.85 (m, 8 H), 5.72 (s, 2 H), 2.79 (s, 3 H), 2.15 (s, 6 H); MS: m/z 297 (M++1).

WORKUP

后处理

  1. concentrationconcentrated in vacuo
  2. filtrationThe insoluble material is filtered