HCID 54374393, compound → HCID 136016629, compound

HRID 1871881Notes

Reaction equation

HRID 1871881 reaction equation
[CH3:1][CH:2]([C:4]1[N:5]=[C:6]([C:12]2[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:13]=2[O:19]CC2C=CC=CC=2)[O:7][C:8]=1[O:9][CH2:10][CH3:11])[CH3:3]>C(OCC)(=O)C.[Pd]>[CH3:1][CH:2]([C:4]1[N:5]=[C:6]([C:12]2[C:13]([OH:19])=[CH:14][CH:15]=[CH:16][C:17]=2[Cl:18])[O:7][C:8]=1[O:9][CH2:10][CH3:11])[CH3:3]

Participants

4

Reactant 1

HCID 54374393HCID 54374393, compound

Product 1

HCID 136016629HCID 136016629, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

0.4 g 4-(2-propyl)-5-ethoxy-2-(2-benzyloxy-6-chlorophenyl)oxazole was dissolved in 10 ml ethyl acetate. To the solution, 5% palladium/carbon in an amount of 0.11 g was further added, and the solution was stirred under hydrogen atmosphere for 15-30 min. at room temperature. The solution reacted was filtrated, then the filtrate was condensed under reduced pressure, affording the objective substance in an amount of 0.28 g.

Workup

  1. customThe solution reacted
  2. filtrationwas filtrated
  3. customcondensed under reduced pressure
  4. customaffording the objective substance in an amount of 0.28 g

Sources & evidence

ORD record
ord-3b82423d4780438cb3cb2eac1923fda2
Source dataset
uspto-grants-2000_08
Patent number
US06107251

Reaction notes

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