Carbonate Ion → HCID 15456861, compound

HRID 1871882Notes

Reaction equation

HRID 1871882 reaction equation
[CH3:1][CH:2]([C:4]1[N:5]=[C:6]([C:12]2[C:17]([OH:18])=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:19])[O:7][C:8]=1[O:9][CH2:10][CH3:11])[CH3:3].CS([C:24]1[N:29]=[C:28]([O:30][CH3:31])[CH:27]=[C:26]([O:32][CH3:33])[N:25]=1)(=O)=O.C(=O)([O-])[O-]>CN(C=O)C>[CH3:1][CH:2]([C:4]1[N:5]=[C:6]([C:12]2[C:17]([O:18][C:24]3[N:29]=[C:28]([O:30][CH3:31])[CH:27]=[C:26]([O:32][CH3:33])[N:25]=3)=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:19])[O:7][C:8]=1[O:9][CH2:10][CH3:11])[CH3:3]

Participants

5

Reactant 3

HCID 19660Carbonate IonHCID 8383634,6-Dimethoxy-2-(methylsulfonyl)pyrimidineHCID 136016629HCID 136016629, compound

Product 1

HCID 15456861HCID 15456861, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
60 °C

Procedure

5 ml DMF solution containing 0.27 g 4-(2-propyl)-5-ethoxy-2-(2-chloro-6-hydroxyphenyl)oxazole, 0.20 g 2-methanesulfonyl-4,6-dimethoxypyrimidine and 0.41 g pottasium carbonate was stirred for 3 hours at 60° C. After completing the reaction, the solution reacted was poured into ice water and then extracted with ethyl acetate. The organic layer obtained was washed with water and saturated saline solution in turn and was then dried by using anhydrous magnesium sulfate, and the solvent used was removed by distillation under reduced pressure. The residue obtained was purified by using silica gel column chromatography, affording the objective oily substance in an amount of 0.3 g.

Workup

  1. customthe reaction
  2. customthe solution reacted
  3. extractionextracted with ethyl acetate
  4. customThe organic layer obtained
  5. washwas washed with water and saturated saline solution in turn
  6. customwas then dried
  7. customthe solvent used was removed by distillation under reduced pressure
  8. customThe residue obtained
  9. customwas purified
  10. customaffording the objective oily substance in an amount of 0.3 g

Sources & evidence

ORD record
ord-0c66534f691d4460b634eedbdbbceb58
Source dataset
uspto-grants-2000_08
Patent number
US06107251

Reaction notes

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