反应详情

To 10 ml methanol, were added 0.52 g 2-(2-formylphenoxy)-4,6-dimethoxypyrimidine), 0.49 g p-toluenesulfonylmethylisocyanide and 0.69 g pottasium carbonate, and the mixture was subjected to reflux with stirring during 15 min. The solution reacted was added with ice, and solid substance precipitated was filtrated. The solid substance obtained was dissolved in ethyl acetate, and the resulting solution was then dried by using anhydrous magnesium sulfate. Then, the solvent used was removed by distillation under reduced pressure, affording the objective substance in an amount of 0.54 g.

1. temperatureto reflux
2. customThe solution reacted
3. additionwas added with ice, and solid substance
4. customprecipitated
5. filtrationwas filtrated
6. customThe solid substance obtained
7. customthe resulting solution was then dried
8. customThen, the solvent used was removed by distillation under reduced pressure
9. customaffording the objective substance in an amount of 0.54 g