反应详情

温度

50 °C

0.24 g silver powder was suspended in 60% aqueous solution of acetic acid in a volume of 3.2 ml, and MEK solution of 0.6 g 5-[2-(4,6-dimethoxypyrimidine-2-yloxy)-6-nitrophenyl]oxazole was fed dropwise thereto at 50° C. while stirring, then the resulting solution was further stirred for 2 hours at 60-70° C. After completing the reaction, the solution reacted was added with ethyl acetate and was filtrated. The filtrate was washed with water and saturated saline solution in turn and was then dried by using anhydrous magnesium sulfate, and the solvent used was removed by distillation under reduced pressure. The residue obtained was purified by using silica gel column chromatography, affording the objective substance in an amount of 0.45 g.

1. stirringthe resulting solution was further stirred for 2 hours at 60-70° C
2. customthe reaction
3. customthe solution reacted
4. filtrationwas filtrated
5. washThe filtrate was washed with water and saturated saline solution in turn
6. customwas then dried
7. customthe solvent used was removed by distillation under reduced pressure
8. customThe residue obtained
9. customwas purified
10. customaffording the objective substance in an amount of 0.45 g