反应详情

A solution of 3-hydroxy-3-(1-phenylsulfonylindol-2-yl)-8-methyl-8-azabicyclo[3.2.1]octane and trifluoroacetic acid in dichloromethane is stirred at room temperature until the dehydration is complete. The reaction mixture is concentrated under reduced pressure and the residue partitioned between dichloromethane and saturated aqueous sodium bicarbonate. The organic phase is separated, washed well with water, washed with saturated aqueous sodium chloride, dried over magnesium sulfate and concentrated under reduced pressure to provide the desired compound.

1. concentrationThe reaction mixture is concentrated under reduced pressure
2. customthe residue partitioned between dichloromethane and saturated aqueous sodium bicarbonate
3. customThe organic phase is separated
4. washwashed well with water
5. washwashed with saturated aqueous sodium chloride
6. dry with materialdried over magnesium sulfate
7. concentrationconcentrated under reduced pressure