反应详情

1-tert-Butoxycarbonyl-4-(2-quinolylmethylene)piperidine (17.6 g) was dissolved in dichloromethane (60 ml), and TFA (60 ml) was added to the solution under cooling on ice. The mixture was stirred for 2.5 hours at room temperature and concentrated under reduced pressure. A saturated solution of sodium hydrogencarbonate was added to the residue to neutralize, and the mixture was then extracted with chloroform. The organic phase was dried over sodium sulfate anhydrate and concentrated under reduced pressure. The title compound was recovered from an etherhexane solvent as white powder. This powder was also used for subsequent reaction without further purification.

1. temperatureunder cooling on ice
2. concentrationconcentrated under reduced pressure
3. additionA saturated solution of sodium hydrogencarbonate was added to the residue
4. extractionthe mixture was then extracted with chloroform
5. dry with materialThe organic phase was dried over sodium sulfate anhydrate
6. concentrationconcentrated under reduced pressure
7. customThe title compound was recovered from an etherhexane solvent as white powder
8. customThis powder was also used for subsequent reaction without further purification