HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-Chloromethyl-4-{2-furylmethylthio)-3-methoxypyridine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Pyridine, 4-chloro-3-methoxy-2-methyl-, 1-oxide | HCID 5083929 | — |
| Reactant | 4-(2-Furylmethylthio)-2-hydroxymethyl-3-methoxypyridine | HCID 18690017 | — |
| Product | 2-Chloromethyl-4-{2-furylmethylthio)-3-methoxypyridine hydrochloride | HCID 22117325 | — |
Reaction Steps
By the procedure described in Aa) to Ac), the intermediate product 4-(2-furylmethylthio)-2-hydroxymethyl-3-methoxypyridine is obtained starting from 4-chloro-3-methoxy-2-methylpyridine N-oxide; m.p. 56-58° C. Chlorination with thionyl chloride by the procedure described in Example Ad) gives the title compound as a beige powder; m.p. 135° C. (decomp.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06107312 |
| Source dataset | uspto-grants-2000_08 |
| ORD ID | ord-e4fbdba7487e4460914c6af1618f1843 |
| Source note | uspto-grants-2000_08 |