HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 86755646, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 5-(5h-Dibenzo[a,d]cyclohepten-5-yl)-2,4(1h,3h)-pyrimidinedione | HCID 11098675 | — |
| Reactant | Methyl 6-(chloromethyl)pyridine-2-carboxylate | HCID 53404482 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 86755646 | HCID 86755646 | — |
Reaction Steps
Cesium carbonate (1.63 g) was added to a stirred solution of the product of step (iv) (1.5 g) in dimethylsulphoxide (20 ml). After 15 minutes triethylamine (0.71 ml) was added followed by the product from step (ii) (1.11 g). The mixture was stirred at room temperature for 4 hours and partitioned between ethyl acetate and water. The organic phase was dried (MgSO4) and evaporated. Purification was by chromatography eluting with 5% methanol in chloroform. Yield 1.86 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06107297 |
| Source dataset | uspto-grants-2000_08 |
| ORD ID | ord-4ec03a1821244395816ee0123f338f18 |
| Source note | uspto-grants-2000_08 |