Cesium carbonate → HCID 18689687, compound

HRID 1871972Notes

Reaction equation

HRID 1871972 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.C(=O)([O-])[O-].[Cs+].[Cs+].[CH:15]1[C:25]2[CH:24]=[CH:23][C:22]3[CH:26]=[CH:27][CH:28]=[CH:29][C:21]=3[CH:20]([C:30]3[C:31](=[O:37])[NH:32][C:33](=[O:36])[NH:34][CH:35]=3)[C:19]=2[CH:18]=[CH:17][CH:16]=1>CS(C)=O>[Cl:1][C:2]1[N:7]=[C:6]([N:34]2[CH:35]=[C:30]([CH:20]3[C:19]4[CH:18]=[CH:17][CH:16]=[CH:15][C:25]=4[CH:24]=[CH:23][C:22]4[CH:26]=[CH:27][CH:28]=[CH:29][C:21]3=4)[C:31](=[O:37])[NH:32][C:33]2=[O:36])[CH:5]=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 10796Cesium carbonateHCID 775312,4-DichloropyrimidineHCID 110986755-(5h-Dibenzo[a,d]cyclohepten-5-yl)-2,4(1h,3h)-pyrimidinedione

Product 1

HCID 18689687HCID 18689687, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

A mixture of 2,4-dichloropyrimidine (1.49 g), cesium carbonate (3.26 g) and the product of example 1 step (iv) (3 g) in dimethylsulphoxide (40 ml) was stirred at room temperature for 3 hours and partitioned between ethyl acetate and water. The organic phase was dried (MgSO4) and evaporated. The product was collected after trituration with 50% ethyl acetate in isohexane. Yield 2.55 g.

Workup

  1. custompartitioned between ethyl acetate and water
  2. dry with materialThe organic phase was dried (MgSO4)
  3. customevaporated
  4. customThe product was collected after trituration with 50% ethyl acetate in isohexane

Sources & evidence

ORD record
ord-c714d4c27d9a409ea749c891f12328f2
Source dataset
uspto-grants-2000_08
Patent number
US06107297

Reaction notes

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