HRID1871979

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cl.O=C(OCc1ccccc1)[C@@H]1C[C@@H](O)CN1

HCID16212860

Benzyl (4R)-4-hydroxy-L-prolinate--hydrogen chloride (1/1)

C12H16ClNO3

结构：Cc1ccc2c(c1)C=Cc1cc(C)ccc1C2c1cn(-c2ccnc(Cl)n2)c(=O)[nH]c1=O

HCID18689750

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc2c(c1)C=Cc1cc(C)ccc1C2c1cn(-c2ccnc(N3C[C@H](O)C[C@H]3C(=O)OCc3ccccc3)n2)c(=O)[nH]c1=O

HCID86755653

未命名化合物

PROCEDURE

实验过程

The subtitle compound was prepared from trans-4-hydroxy-L-proline benzyl ester hydrochloride (0.928 g) and the product of example 8 step (ii) (0.3 g) by the method of example 10 step (ii). Purification was by chromatography eluting with 50-60% ethyl acetate in isohexane. Yield 0.29 g.

WORKUP

后处理

customPurification
washeluting with 50-60% ethyl acetate in isohexane

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4134fa5a93ab4867bb635838b11dc9fa
来源数据集: uspto-grants-2000_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06107297
来源说明: uspto-grants-2000_08

反应 SMILES

Cl.[CH2:2]([O:9][C:10](=[O:17])[C@@H:11]1[CH2:15][C@@H:14]([OH:16])[CH2:13][NH:12]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Cl[C:19]1[N:24]=[C:23]([N:25]2[CH:30]=[C:29]([CH:31]3[C:37]4[CH:38]=[CH:39][C:40]([CH3:42])=[CH:41][C:36]=4[CH:35]=[CH:34][C:33]4[CH:43]=[C:44]([CH3:47])[CH:45]=[CH:46][C:32]3=4)[C:28](=[O:48])[NH:27][C:26]2=[O:49])[CH:22]=[CH:21][N:20]=1>>[CH3:42][C:40]1[CH:39]=[CH:38][C:37]2[CH:31]([C:29]3[C:28](=[O:48])[NH:27][C:26](=[O:49])[N:25]([C:23]4[CH:22]=[CH:21][N:20]=[C:19]([N:12]5[CH2:13][C@H:14]([OH:16])[CH2:15][C@H:11]5[C:10]([O:9][CH2:2][C:3]5[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=5)=[O:17])[N:24]=4)[CH:30]=3)[C:32]3[CH:46]=[CH:45][C:44]([CH3:47])=[CH:43][C:33]=3[CH:34]=[CH:35][C:36]=2[CH:41]=1