HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl (4R)-4-hydroxy-L-prolinate--hydrogen chloride (1/1) → (2S-trans)-N-[4-[5-{2,8-Dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl}-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl]pyrimidin-2-yl]-4-hydroxy-2-pyrrolidinecarboxylic acid, phenylmethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl (4R)-4-hydroxy-L-prolinate--hydrogen chloride (1/1) | HCID 16212860 | — |
| Reactant | 1-[2-Chloropyrimidin-4-yl}-5-[2,8-dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl]-2,4(1H,3H)-pyrimidinedione | HCID 18689750 | — |
| Product | (2S-trans)-N-[4-[5-{2,8-Dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl}-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl]pyrimidin-2-yl]-4-hydroxy-2-pyrrolidinecarboxylic acid, phenylmethyl ester | HCID 86755653 | — |
Reaction Steps
The subtitle compound was prepared from trans-4-hydroxy-L-proline benzyl ester hydrochloride (0.928 g) and the product of example 8 step (ii) (0.3 g) by the method of example 10 step (ii). Purification was by chromatography eluting with 50-60% ethyl acetate in isohexane. Yield 0.29 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06107297 |
| Source dataset | uspto-grants-2000_08 |
| ORD ID | ord-4134fa5a93ab4867bb635838b11dc9fa |
| Source note | uspto-grants-2000_08 |