1-[2-Chloropyrimidin-4-yl}-5-[2,8-dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl]-2,4(1H,3H)-pyrimidinedione → HCID 178501394, compound

HRID 1871980Notes

Reaction equation

HRID 1871980 reaction equation
Cl.Cl.[CH3:3][O:4][C:5](=[O:14])[C@H:6]([CH2:8][C:9]1[N:13]=[CH:12][NH:11][CH:10]=1)[NH2:7].Cl[C:16]1[N:21]=[C:20]([N:22]2[CH:27]=[C:26]([CH:28]3[C:34]4[CH:35]=[CH:36][C:37]([CH3:39])=[CH:38][C:33]=4[CH:32]=[CH:31][C:30]4[CH:40]=[C:41]([CH3:44])[CH:42]=[CH:43][C:29]3=4)[C:25](=[O:45])[NH:24][C:23]2=[O:46])[CH:19]=[CH:18][N:17]=1>>[CH3:39][C:37]1[CH:36]=[CH:35][C:34]2[CH:28]([C:26]3[C:25](=[O:45])[NH:24][C:23](=[O:46])[N:22]([C:20]4[CH:19]=[CH:18][N:17]=[C:16]([NH:7][C@H:6]([C:5]([O:4][CH3:3])=[O:14])[CH2:8][C:9]5[N:13]=[CH:12][NH:11][CH:10]=5)[N:21]=4)[CH:27]=3)[C:29]3[CH:43]=[CH:42][C:41]([CH3:44])=[CH:40][C:30]=3[CH:31]=[CH:32][C:33]=2[CH:38]=1

Participants

3

Reactant 2

HCID 186897501-[2-Chloropyrimidin-4-yl}-5-[2,8-dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl]-2,4(1H,3H)-pyrimidinedioneHCID 178419105HCID 178419105, compound

Product 1

HCID 178501394HCID 178501394, compound

Procedure

The subtitle compound was prepared from L-histidine methyl ester dihydrochloride (1.15 g) and the product of example 8 step (ii) (0.7 g) by the method of example 10 step (ii). Purification was by chromatography eluting with 5-10% methanol in dichloromethane. Yield 0.25 g.

Workup

  1. customPurification
  2. washeluting with 5-10% methanol in dichloromethane

Sources & evidence

ORD record
ord-15a8f34e616c4882a495e3d9c8d39709
Source dataset
uspto-grants-2000_08
Patent number
US06107297

Reaction notes

Loading…