HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 1-(Bromomethyl)-3-ethylbenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Phosphorus tribromide | HCID 24614 | — |
| Reactant | (3-Ethylphenyl)methanol | HCID 104659 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 1-(Bromomethyl)-3-ethylbenzene | HCID 22003656 | — |
Reaction Steps
Phosphorous tribromide (5.3 ml) was added to a solution of the product from step (i) (7.6 g) in benzene (150 ml) at 0° C. After 3 hours, water (40 ml) was added and the mixture warmed to room temperature and extracted with ethyl acetate. The organic phase was dried (MgSO4) and evaporated. Purified by chromatography eluting with 2% ethyl acetate in isohexane. Yield 8.0 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06107297 |
| Source dataset | uspto-grants-2000_08 |
| ORD ID | ord-b501f9e1eb8544469e9e0de14223e35f |
| Source note | uspto-grants-2000_08 |