反应详情

A mixture of the product of step (ii) (0.52 g), the product of example 8 step (i) (0.5 g) and cesium carbonate (0.49 g) in dimethylformamide (15 ml) was heated at 70° C. After 3 hours, the reaction mixture was partitioned between 1M HCl and ethyl acetate. The organic phase was washed with water, dried (MgSO4) and evaporated under reduced pressure. Purification was by chromatography eluting with 3% methanol in chloroform. Yield 0.47 g.

1. customthe reaction mixture was partitioned between 1M HCl and ethyl acetate
2. washThe organic phase was washed with water
3. dry with materialdried (MgSO4)
4. customevaporated under reduced pressure
5. customPurification
6. washeluting with 3% methanol in chloroform