HRID1871990

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10796

Cesium carbonate

CCs2O3

结构：CCc1ccc2c(c1)C=Cc1cc(C)ccc1C2c1c[nH]c(=O)[nH]c1=O

HCID22117281

未命名化合物

HCID131721952

未命名化合物

PRODUCTS

生成物

结构：CCc1ccc2c(c1)C=Cc1cc(C)ccc1C2c1cn(-c2ccnc(N(C)CC(=O)OC)n2)c(=O)[nH]c1=O

HCID131721953

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID13387

N-Methyl-2-pyrrolidone

C5H9NO

PROCEDURE

实验过程

A mixture of the product of step (i) (0.68 g), and the product of example 15 step (vii) (2.35 g) was stirred with cesium carbonate (2.22 g) in 1-methyl-2-pyrrolidinone (20 ml) at 70-80° C. for 4 hours. The reaction mixture was partitioned between ethyl acetate and brine. The organic layer was dried (MgSO4) and evaporated under reduced pressure. The residue was purified by chromatography eluting with ethyl acetate in toluene. Yield 0.57 g.

WORKUP

后处理

customThe reaction mixture was partitioned between ethyl acetate and brine
dry with materialThe organic layer was dried (MgSO4)
customevaporated under reduced pressure
customThe residue was purified by chromatography
washeluting with ethyl acetate in toluene

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ca59f79ee1fc4f0a964c9d4dbab2540b
来源数据集: uspto-grants-2000_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06107297
来源说明: uspto-grants-2000_08

反应 SMILES

F[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([N:8]([CH3:14])[CH2:9][C:10]([O:12][CH3:13])=[O:11])[N:3]=1.[CH2:15]([C:17]1[CH:40]=[CH:39][C:20]2[CH:21]([C:31]3[C:32](=[O:38])[NH:33][C:34](=[O:37])[NH:35][CH:36]=3)[C:22]3[CH:29]=[CH:28][C:27]([CH3:30])=[CH:26][C:23]=3[CH:24]=[CH:25][C:19]=2[CH:18]=1)[CH3:16].C(=O)([O-])[O-].[Cs+].[Cs+]>CN1CCCC1=O>[CH2:15]([C:17]1[CH:40]=[CH:39][C:20]2[CH:21]([C:31]3[C:32](=[O:38])[NH:33][C:34](=[O:37])[N:35]([C:2]4[CH:7]=[CH:6][N:5]=[C:4]([N:8]([CH3:14])[CH2:9][C:10]([O:12][CH3:13])=[O:11])[N:3]=4)[CH:36]=3)[C:22]3[CH:29]=[CH:28][C:27]([CH3:30])=[CH:26][C:23]=3[CH:24]=[CH:25][C:19]=2[CH:18]=1)[CH3:16]