Water → HCID 178435472, compound

HRID 1871993Notes

Reaction equation

HRID 1871993 reaction equation
[CH2:1]([C:3]1[CH:26]=[CH:25][C:6]2[CH:7]([C:17]3[C:18](=[S:24])[NH:19][C:20](=[O:23])[NH:21][CH:22]=3)[C:8]3[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:9]=3[CH:10]=[CH:11][C:5]=2[CH:4]=1)[CH3:2].O.[C:28](=O)(O)[O-].[Na+].IC>C(O)C>[CH2:1]([C:3]1[CH:26]=[CH:25][C:6]2[CH:7]([C:17]3[C:18]([S:24][CH3:28])=[N:19][C:20](=[O:23])[NH:21][CH:22]=3)[C:8]3[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:9]=3[CH:10]=[CH:11][C:5]=2[CH:4]=1)[CH3:2]

Participants

6

Reactant 4

HCID 962WaterHCID 6328Methyl iodideHCID 516892Sodium BicarbonateHCID 18689767HCID 18689767, compound

Product 1

HCID 178435472HCID 178435472, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The product of step (iii) (0.58 g) was dissolved in ethanol (30 ml) and water (5 ml) and treated with sodium bicarbonate(0.14 g) and iodomethane (0.2 ml) and stirred for 24 hours. The reaction mixture was partitioned between ethyl acetate and brine. The organic phase was dried (MgSO4) and solvent evaporated under reduced pressure. The residue was triturated with isohexane and filtered to give the product. Yield 0.41 g.

Workup

  1. customThe reaction mixture was partitioned between ethyl acetate and brine
  2. dry with materialThe organic phase was dried (MgSO4) and solvent
  3. customevaporated under reduced pressure
  4. customThe residue was triturated with isohexane
  5. filtrationfiltered
  6. customto give the product

Sources & evidence

ORD record
ord-fb51028a58cd4abbb2c17d5c242e8c7b
Source dataset
uspto-grants-2000_08
Patent number
US06107297

Reaction notes

Loading…