Cesium carbonate → HCID 86755658, compound

HRID 1871994Notes

Reaction equation

HRID 1871994 reaction equation
[CH2:1]([C:3]1[CH:27]=[CH:26][C:6]2[CH:7]([C:17]3[C:18]([S:24][CH3:25])=[N:19][C:20](=[O:23])[NH:21][CH:22]=3)[C:8]3[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:9]=3[CH:10]=[CH:11][C:5]=2[CH:4]=1)[CH3:2].F[C:29]1[CH:34]=[CH:33][N:32]=[C:31]([N:35]([CH3:51])[CH2:36][C:37]([NH:39][C:40]2[S:41][CH:42]=[C:43]([CH2:45][C:46]([O:48][CH2:49][CH3:50])=[O:47])[N:44]=2)=[O:38])[N:30]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>CN1CCCC1=O>[CH2:1]([C:3]1[CH:27]=[CH:26][C:6]2[CH:7]([C:17]3[C:18]([S:24][CH3:25])=[N:19][C:20](=[O:23])[N:21]([C:29]4[CH:34]=[CH:33][N:32]=[C:31]([N:35]([CH3:51])[CH2:36][C:37]([NH:39][C:40]5[S:41][CH:42]=[C:43]([CH2:45][C:46]([O:48][CH2:49][CH3:50])=[O:47])[N:44]=5)=[O:38])[N:30]=4)[CH:22]=3)[C:8]3[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:9]=3[CH:10]=[CH:11][C:5]=2[CH:4]=1)[CH3:2]

Participants

5

Reactant 3

HCID 10796Cesium carbonateHCID 86755657HCID 86755657, compoundHCID 178435472HCID 178435472, compound

Product 1

HCID 86755658HCID 86755658, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

The product of step (iv) (0.37 g), and the product of step (ii) (0.35 g) was stirred with cesium carbonate (0.32 g) in dry 1-methyl-2-pyrrolidinone (15 ml) at 65-70° C. for 20 hours. The reaction mixture was partitioned between ethyl acetate and brine. The organic layer collected, dried (MgSO4), and solvent evaporated under reduced pressure. Yield 0.61 g.

Workup

  1. customThe reaction mixture was partitioned between ethyl acetate and brine
  2. customThe organic layer collected
  3. dry with materialdried (MgSO4), and solvent
  4. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-1445cbdf53d5421b999b332b9a9d346b
Source dataset
uspto-grants-2000_08
Patent number
US06107297

Reaction notes

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