Methyl iodide → HCID 178503573, compound

HRID 1871998Notes

Reaction equation

HRID 1871998 reaction equation
IC.[CH3:3][C:4]1[CH:27]=[CH:26][C:7]2[CH:8]([C:18]3[C:19](=[S:25])[NH:20][C:21](=[O:24])[NH:22][CH:23]=3)[C:9]3[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][C:10]=3[CH:11]=[CH:12][C:6]=2[CH:5]=1.[C:28](=O)(O)[O-].[Na+]>C(O)C.O>[CH3:3][C:4]1[CH:27]=[CH:26][C:7]2[CH:8]([C:18]3[C:19]([S:25][CH3:28])=[N:20][C:21](=[O:24])[NH:22][CH:23]=3)[C:9]3[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][C:10]=3[CH:11]=[CH:12][C:6]=2[CH:5]=1

Participants

6

Reactant 3

HCID 6328Methyl iodideHCID 516892Sodium BicarbonateHCID 18689719HCID 18689719, compound

Product 1

HCID 178503573HCID 178503573, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

Iodomethane (0.2 ml) was added to a stirred suspension of the product from step (i) (0.65 g) and sodium bicarbonate (0.4 g) in ethanol (15 ml) and water (4 ml). After stirring for 30 min, the reaction mixture was washed with water, 1M hydrochloric acid, aqueous sodium bicarbonate, water, dried (MgSO4) and evaporated under reduced pressure. The residue was triturated with ether and filtered. Yield 0.49 g.

Workup

  1. washthe reaction mixture was washed with water, 1M hydrochloric acid, aqueous sodium bicarbonate, water
  2. dry with materialdried (MgSO4)
  3. customevaporated under reduced pressure
  4. customThe residue was triturated with ether
  5. filtrationfiltered

Sources & evidence

ORD record
ord-19a02dd9780f4f77a7f4c8e0c691c1ba
Source dataset
uspto-grants-2000_08
Patent number
US06107297

Reaction notes

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