HCID 54492963, compound → HCID 22117269, compound

HRID 1872005Notes

Reaction equation

HRID 1872005 reaction equation
CC1C=CC2C(C3C(=O)NC(=O)N(C4C=CN=C(NCC(NC5SC=C(CC(O)=O)N=5)=O)N=4)C=3)C3C=CC(CCC)=CC=3C=CC=2C=1.[CH3:48][C:49]1[CH:57]=[CH:56][C:52]([C:53]([OH:55])=[O:54])=[C:51]([CH2:58][CH2:59][C:60]2[CH:65]=[CH:64][CH:63]=[C:62]([CH:66]=[CH:67][CH3:68])[CH:61]=2)[CH:50]=1>C(OCC)(=O)C.[Pd]>[CH3:48][C:49]1[CH:57]=[CH:56][C:52]([C:53]([OH:55])=[O:54])=[C:51]([CH2:58][CH2:59][C:60]2[CH:65]=[CH:64][CH:63]=[C:62]([CH2:66][CH2:67][CH3:68])[CH:61]=2)[CH:50]=1

Participants

5

Reactant 2

HCID 54492963HCID 54492963, compoundHCID 54554180HCID 54554180, compound

Product 1

HCID 22117269HCID 22117269, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

The subtitle compound was prepared from the product of step (iv) (15.4 g) by the method of example 15 step (v). The crude reaction product was contaminated with 4-methyl-2-[2-[3-[1-propenyl]phenyl]ethyl]benzoic acid. The crude reaction product was dissolved in ethyl acetate (100 ml) and the solution was hydrogenated over 10% palladium on carbon (1 g) at 3 atmospheres pressure for 2 hours. The catalyst was removed by filtration and the filtrate was evaporated. Yield 12.8 g.

Workup

  1. customThe crude reaction product
  2. customThe crude reaction product
  3. customThe catalyst was removed by filtration
  4. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-1c5acd0ca0cc4f98bc7380f88f66b19c
Source dataset
uspto-grants-2000_08
Patent number
US06107297

Reaction notes

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