(+/-)-5-[2-Ethyl-8-methyl-5H-dibenzo[a,d]cyclohepten-5-yl]-2,4(1H,3H)-pyrimidinedione → (+/-) 2-[5-{2-Ethyl-8-methyl-5H-dibenzo[a,d]cyclohepten-5-yl}-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl]-4-pyrimidinecarboxylic acid, (1,1-dimethylethyl) ester

HRID 1872015Notes

Reaction equation

HRID 1872015 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH:5]=[CH:4][N:3]=1.[CH2:15]([C:17]1[CH:40]=[CH:39][C:20]2[CH:21]([C:31]3[C:32](=[O:38])[NH:33][C:34](=[O:37])[NH:35][CH:36]=3)[C:22]3[CH:29]=[CH:28][C:27]([CH3:30])=[CH:26][C:23]=3[CH:24]=[CH:25][C:19]=2[CH:18]=1)[CH3:16]>>[CH2:15]([C:17]1[CH:40]=[CH:39][C:20]2[CH:21]([C:31]3[C:32](=[O:38])[NH:33][C:34](=[O:37])[N:35]([C:2]4[N:7]=[C:6]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH:5]=[CH:4][N:3]=4)[CH:36]=3)[C:22]3[CH:29]=[CH:28][C:27]([CH3:30])=[CH:26][C:23]=3[CH:24]=[CH:25][C:19]=2[CH:18]=1)[CH3:16]

Participants

3

Reactant 2

HCID 22117281(+/-)-5-[2-Ethyl-8-methyl-5H-dibenzo[a,d]cyclohepten-5-yl]-2,4(1H,3H)-pyrimidinedioneHCID 57063961tert-Butyl 2-chloropyrimidine-4-carboxylate

Product 1

HCID 131721956(+/-) 2-[5-{2-Ethyl-8-methyl-5H-dibenzo[a,d]cyclohepten-5-yl}-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl]-4-pyrimidinecarboxylic acid, (1,1-dimethylethyl) ester

Procedure

The subtitle compound was prepared from the product of step (iii) and the product of example 15 step (vii) by the method of example 19 step (ii).

Sources & evidence

ORD record
ord-366c72ac2d5640428acd677cb13469af
Source dataset
uspto-grants-2000_08
Patent number
US06107297

Reaction notes

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