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HRID1872164

反应详情

EQUATION

反应方程式

HRID 1872164 的结构方程式

REACTANTS

反应物

2
结构：CNC.Cl
HCID10473

N-Methylmethanamine hydrochloride

C2H8ClN

结构：CC(C)(C)OC(=O)N[C@@H](Cc1ccc(N)cc1)C(=O)O
HCID2761482

4-Amino-N-(tert-butoxycarbonyl)-L-phenylalanine

C14H20N2O4

PRODUCTS

生成物

1
结构：CN(C)C(=O)[C@H](Cc1ccc(N)cc1)NC(=O)OC(C)(C)C
HCID20679220

未命名化合物

PROCEDURE

实验过程

Dimethylamine hydrochloride (2.04 mmol) and Boc-p-amino-L-phenylalanine (1.7 mmol) were coupled according to Procedure A (0-25° C. reaction temperature, 4:1 dichloro-methaneldimethylformamide reaction solvent, washed with base only). The product was purified by chromatography on silica gel eluted with 50, 60, 70 and 100% ethyl acetate in hexanes. Yield 226 mg, 42%; HPLC (70/30) 2.45 minutes (100%).

WORKUP

后处理

  1. custom0-25° C. reaction temperature, 4:1 dichloro-methaneldimethylformamide reaction solvent
  2. washwashed with base only)
  3. customThe product was purified by chromatography on silica gel
  4. washeluted with 50, 60, 70 and 100% ethyl acetate in hexanes
  5. customHPLC (70/30) 2.45 minutes (100%)