Hydrochloric Acid → HCID 23458864, compound

HRID 1872203Notes

Reaction equation

HRID 1872203 reaction equation
C([NH:4][C:5]([CH2:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[NH:24][CH2:25][CH2:26][N:27]=2)=[CH:19][CH:18]=1)(C(OCC)=O)[C:6]([O:8]CC)=[O:7])(=O)C.[ClH:28]>C(O)(=O)C>[ClH:28].[ClH:28].[NH2:4][CH:5]([CH2:16][C:17]1[CH:18]=[CH:19][C:20]([C:23]2[NH:27][CH2:26][CH2:25][N:24]=2)=[CH:21][CH:22]=1)[C:6]([OH:8])=[O:7]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54151293HCID 54151293, compound

Product 1

HCID 23458864HCID 23458864, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To 2-acetylamino-2-[4-(4,5-dihydro-1H-imidazol-2-yl)-benzyl]-malonic acid, diethyl ester (3.0 g, 7.3 mmol) was added glacial acetic acid (50 mL) and 3N HCl (100 mL). The solution was heated to reflux for 3 hours, cooled and concentrated to a white solid which was recrystallized from methanol/ether (2.0 g, mp 270-272° C. dec.).

Workup

  1. temperatureThe solution was heated
  2. temperatureto reflux for 3 hours
  3. temperaturecooled
  4. concentrationconcentrated to a white solid which
  5. customwas recrystallized from methanol/ether (2.0 g, mp 270-272° C. dec.)

Sources & evidence

ORD record
ord-741c7f6b20ee4626b0c1d9fec80ca4ef
Source dataset
uspto-grants-2000_08
Patent number
US06107329

Reaction notes

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