5,7-Difluoro-1H-indole-2-carboxylic acid → (s)-5,7-Difluoro-1h-indole-2-carboxylic acid (1-benzyl-2-oxo-2-thiazolidin-3-yl-ethyl)-amide

HRID 1872206Notes

Reaction equation

HRID 1872206 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([F:11])[CH:10]=1)[NH:7][C:6]([C:12]([OH:14])=O)=[CH:5]2.[NH2:15][C@@H:16]([CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:17]([N:19]1[CH2:23][CH2:22][S:21][CH2:20]1)=[O:18]>>[CH2:24]([C@H:16]([NH:15][C:12]([C:6]1[NH:7][C:8]2[C:4]([CH:5]=1)=[CH:3][C:2]([F:1])=[CH:10][C:9]=2[F:11])=[O:14])[C:17](=[O:18])[N:19]1[CH2:23][CH2:22][S:21][CH2:20]1)[C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

3

Reactant 2

HCID 167892455,7-Difluoro-1H-indole-2-carboxylic acidHCID 53999780(s)-2-Amino-3-phenyl-1-thiazolidin-3-yl-propan-1-one

Product 1

HCID 54472052(s)-5,7-Difluoro-1h-indole-2-carboxylic acid (1-benzyl-2-oxo-2-thiazolidin-3-yl-ethyl)-amide

Procedure

From 5,7-difluoro-1H-indole-2-carboxylic acid and (S)-2-amino-3-phenyl-1-thiazolidin-3-yl-propan-1-one. mp 175-185° C.

Sources & evidence

ORD record
ord-9965287e69594587ba9c5bf677391a3e
Source dataset
uspto-grants-2000_08
Patent number
US06107329

Reaction notes

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