3-Acetoxymethyl-1-(4-methoxy-benzenesulfonyl)-azepane-2-carboxylic acid → 3-Acetoxymethyl-1-(4-methoxy-benzenesulfonyl)-2,3,4,7-tetrahydro-1H-azepine-2-carboxylic acid

HRID 1872246Notes

Reaction equation

HRID 1872246 reaction equation
C(OC(C1C(CO)CC=CCN1S(C1C=CC(OC)=CC=1)(=O)=O)=O)(C)(C)C.[C:28]([O:31][CH2:32][CH:33]1[CH2:39][CH2:38][CH2:37][CH2:36][N:35]([S:40]([C:43]2[CH:48]=[CH:47][C:46]([O:49][CH3:50])=[CH:45][CH:44]=2)(=[O:42])=[O:41])[CH:34]1[C:51]([OH:53])=[O:52])(=[O:30])[CH3:29]>>[C:28]([O:31][CH2:32][CH:33]1[CH2:39][CH:38]=[CH:37][CH2:36][N:35]([S:40]([C:43]2[CH:44]=[CH:45][C:46]([O:49][CH3:50])=[CH:47][CH:48]=2)(=[O:42])=[O:41])[CH:34]1[C:51]([OH:53])=[O:52])(=[O:30])[CH3:29]

Participants

3

Reactant 2

HCID 186896413-Acetoxymethyl-1-(4-methoxy-benzenesulfonyl)-azepane-2-carboxylic acidHCID 538968433-Hydroxymethyl-1-(4-methoxy-benzenesulfonyl)-2,3,4,7-tetrahydro-1H-azepine-2-carboxylic acid tert butyl ester

Product 1

HCID 186896583-Acetoxymethyl-1-(4-methoxy-benzenesulfonyl)-2,3,4,7-tetrahydro-1H-azepine-2-carboxylic acid

Procedure

3-Acetoxymethyl-1-(4-methoxy-benzenesulfonyl)-2,3,4,7-tetrahydro-1H-azepine-2-carboxylic acid was synthesized from 3-Hydroxymethyl-1-(4-methoxy-benzenesulfonyl)-2,3,4,7-tetrahydro-1H-azepine-2-carboxylic acid tert butyl ester in the same manner as the procedures used for the preparation of 3-Acetoxymethyl-1-(4-methoxy-benzenesulfonyl)-azepane-2-carboxylic acid: MS (M-H)- =382.

Sources & evidence

ORD record
ord-136873d6ec9e4bc1b908d2dd452a7c35
Source dataset
uspto-grants-2000_08
Patent number
US06107291

Reaction notes

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