3-Hydroxymethyl-1-(4-methoxybenzenesulfonyl)-azepane-2-carboxylic acid → 3-Hydroxymethyl-1-(4-methoxy-benzenesulfonyl)-2,3,4,7-tetrahydro-1H-azepine-2-carboxylic acid hydroxyamide
Reaction equation
[OH:1][NH:2][C:3]([CH:5]1[CH:11]([CH2:12][O:13]C(=O)C)[CH2:10][CH:9]=[CH:8][CH2:7][N:6]1[S:17]([C:20]1[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=1)(=[O:19])=[O:18])=[O:4].OCC1CCCCN(S(C2C=CC(OC)=CC=2)(=O)=O)C1C(O)=O>>[OH:1][NH:2][C:3]([CH:5]1[CH:11]([CH2:12][OH:13])[CH2:10][CH:9]=[CH:8][CH2:7][N:6]1[S:17]([C:20]1[CH:21]=[CH:22][C:23]([O:26][CH3:27])=[CH:24][CH:25]=1)(=[O:19])=[O:18])=[O:4]Participants
3
Reactant 2
Product 1
Procedure
3-Hydroxymethyl-1-(4-methoxy-benzenesulfonyl)-2,3,4,7-tetrahydro-1H-azepine-2-carboxylic acid hydroxyamide was synthesized from Acetic acid 2-hydroxycarbamoyl-1-(4-methoxy-benzenesulfonyl)-2,3,4,7-tetrahydro-1H-azepin-3-ylmethyl ester in the same manner as the procedures used for the preparation of 3-Hydroxymethyl-1-(4-methoxybenzenesulfonyl)-azepane-2-carboxylic acid hydroxamide: MS (M-H)- =355.
Sources & evidence
- ORD record
- ord-f698e69c0213446eb66835d5fc301b54
- Source dataset
- uspto-grants-2000_08
- Patent number
- US06107291
Reaction notes
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