3-Hydroxymethyl-1-(4-methoxy-benzenesulfonyl)-2,3,4,7-tetrahydro-1H-azepine-2-carboxylic acid tert butyl ester → 1-(4-Methoxy-benzenesulfonyl)-3-phenylsulfanylmethyl-2,3,4,7-tetrahydro-1H-azepine-2-carboxylic acid tert-butyl ester

HRID 1872250Notes

Reaction equation

HRID 1872250 reaction equation
C(OC(C1C(CO)CC=CCN1S(C1C=CC(OC)=CC=1)(=O)=O)=O)(C)(C)C.[C:28]([O:32][C:33]([CH:35]1[CH:41]([CH2:42][S:43][C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)[CH2:40][CH2:39][CH2:38][CH2:37][N:36]1[S:50]([C:53]1[CH:58]=[CH:57][C:56]([O:59][CH3:60])=[CH:55][CH:54]=1)(=[O:52])=[O:51])=[O:34])([CH3:31])([CH3:30])[CH3:29]>>[C:28]([O:32][C:33]([CH:35]1[CH:41]([CH2:42][S:43][C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)[CH2:40][CH:39]=[CH:38][CH2:37][N:36]1[S:50]([C:53]1[CH:58]=[CH:57][C:56]([O:59][CH3:60])=[CH:55][CH:54]=1)(=[O:52])=[O:51])=[O:34])([CH3:31])([CH3:30])[CH3:29]

Participants

3

Reactant 2

HCID 538968433-Hydroxymethyl-1-(4-methoxy-benzenesulfonyl)-2,3,4,7-tetrahydro-1H-azepine-2-carboxylic acid tert butyl esterHCID 543100941-(4-Methoxy-benzenesulfonyl)-3-phenylsulfanylmethyl-azepane-2-carboxylic acid tert-butyl ester

Product 1

HCID 540098641-(4-Methoxy-benzenesulfonyl)-3-phenylsulfanylmethyl-2,3,4,7-tetrahydro-1H-azepine-2-carboxylic acid tert-butyl ester

Procedure

1-(4-Methoxy-benzenesulfonyl)-3-phenylsulfanylmethyl-2,3,4,7-tetrahydro-1H-azepine-2-carboxylic acid tert-butyl ester was synthesized from 3-Hydroxymethyl-1-(4-methoxy-benzenesulfonyl)-2,3,4,7-tetrahydro-1H-azepine-2-carboxylic acid tert butyl ester in the same manner as the procedures used for the preparation of 1-(4-Methoxy-benzenesulfonyl)-3-phenylsulfanylmethyl-azepane-2-carboxylic acid tert-butyl ester: MS (M+H)+ =490, (M+NH4)+ =507.

Sources & evidence

ORD record
ord-7bb8bed0884a4c7fb6ccca1dac7fc824
Source dataset
uspto-grants-2000_08
Patent number
US06107291

Reaction notes

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